It would appear that I still have problems, thought it was too good to be true. Having shut the PC down for the weekend, I have returned to work today to find that the PC didn't shut down and two editor windows (Akelpad) open with Russian italics inplace of the usual file menu titles. After reboot all seemed normal but then when I came online using Firefox to view the forum, after several minutes the network was real busy. So it would appear that a backdoor has been created and accessed.
I have run the TDSSKiller and it has again found another route kit. I have rebooted an the route kit has been removed. I have now un-installed Firefox and deleted all of it's folders. I am browsing noe with Opera and and the network is stable with no activity.
At this point I do not know if I can trust that my PC is out of the clear. I am preparing back-ups with the intention of formatting my C: drive if things do not settle down. It's now become a case of practicality and it simply isn't practical to spend another week trying to hunt this problem down.
Any further help or advice gratefully appreciated.